Efficient Synthesis of 2-Aminothiazoles and Fanetizole in Liquid PEG-400 at Ambient Conditions

A simple and practical procedure for the synthesis of 2-aminothiazoles from α-tosyloxyketones and thioureas is described using PEG-400[poly(ethylene glycol-400)] at ambient conditions. The developed protocol is successfully applied for the preparation of an anti-inflammatory drug, Fanetizole.