Crystal structural analysis and metal-dependent stability and activity studies of the ColE7 endonuclease domain in complex with

For locking individual gears, a "rod-type" locking element is provided which extends in the axial direction over several operating elements and which, in the individual possible transmission shifting positions, in each case, engages with some of the existing operating elements. When one of the operating elements is shifted out of its neutral position into a shifting position, the locking rod is brought into a locking engagement with at least some of the existing operating elements.