Total Synthesis of Natural Lembehyne C and Investigation of Its Cytotoxic Properties.

Lilya U. Dzhemileva,Vladimir A. D'yakonov,Alexey A. Makarov,Elina Kh. Makarova,Evgeny N. Andreev,Usein M. Dzhemilev

Total Synthesis of Natural Lembehyne C and Investigation of Its Cytotoxic Properties.

2020

Lilya U. Dzhemileva
Vladimir A. D'yakonov
Alexey A. Makarov
Elina Kh. Makarova
Evgeny N. Andreev
Usein M. Dzhemilev

The first Z-stereoselective method for the synthesis of the natural marine alkynol lembehyne C, containing a 1Z,5Z,9Z-triene moiety, in 41% yield was developed using the new Ti-catalyzed cross-coup...

Keywords:

Cytotoxic T cell
Moiety
Total synthesis
Cell cycle
mitochondrial pathway
Jurkat cells
Biochemistry
Biology
Stereochemistry

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