Early Application of Atorvastatin on Long-term Efficacy in Patients with Acute Crownary Syndrome

Objective To observe intervention effect of atorvastatin in patients with acute coronary syndrome of early inflammatory factors and cardiovascular and cerebrovascular events.Methods Totally 53 patients with ACS were randomly assigned to atorvastatin treatment group (n=29) and conventional control group (n=24).Atorvastatin treatment group based on the control group conventional therapy plus atorvastatin 20mg,per night 1 service.all patients at 24h and admitted to hospital and treatment 1 month later the fasting blood one time to measure lipids,hs-CRP,MMP-9.While observing the 6 month follow-up,the main cardio-cerebral vascular events.Results After 4 weeks of atorvastatin treatment group compared with the control group,patients with TC,TG,hs-CRP and MMP-9 levels were significantly decreased (both P0.01),while the control group,no statistical difference before and after therapy (P0.05).Atorvastatin treatment group,6-month follow-up period recurrent angina,arrhythmia,heart failure and non-fatal myocardial infarction was significantly lower than those in normal controls (P0.05).Conclusion Early treatment of ACS atorvastatin can inhibit inflammatory cytokines and reduce follow-up period of six months,the incidence of major cardiovascular events.