Pretreatment with atorvastatin ameliorates lung injury caused by high-pressure/high-tidal-volume mechanical ventilation in isolated normal rabbit lungs

Previous animal studies revealed that administration of statins ameliorates lung injury following endotoxin exposure or ischemia-reperfusion. In this experiment, we endeavored to investigate whether pretreatment with atorvastatin confers protection from lung injury caused by high-pressure/high-tidal-volume ventilation.