Where are we on (preventing) pneumothorax after (cone-beam) computed tomography-guided lung biopsy?

In patients with lung lesions obtaining histology of the lesion plays an important role in obtaining the diagnosis and therapy planning. Most patients undergo bronchoscopy in order to obtain a tissue sample of the lesion. However, success rates leading to a diagnosis ranges from 30-80% depending on the sampling method (biopsy, fine needle aspiration or bronchoalveolar lavage) (1).