The Investigation of Relationship between Coronary Artery Ectasia, Benign Prostatic Enlargement, and Lower Urinary Tract Symptoms

Objective To investigate benign prostatic enlargement (BPE) and lower urinary tract symptoms (LUTS) in patients with coronary artery ectasia (CAE). The relation between CAE, BPE, and LUTS has not been studied so far. Methods We investigated BPE and LUTS symptoms in 47 men with CAE, 45 men with coronary artery disease (CAD), and 47 male controls with normal coronary arteries. LUTS was evaluated by the International Prostate Symptom Score (IPSS). BPE was evaluated with transabdominal ultrasonography. CAD was defined as myocardial infarction and angiographically diagnosed coronary disease. CAE was defined as being without any stenotic lesions with a visual assessment of the coronary arteries showing a luminal dilatation ≥1.5 fold of the adjacent normal coronary segments. Results Prostate volume was higher in CAE and CAD patients compared with that of the control subjects, respectively (41.0 ± 10.4 vs 33.5 ± 9.4 cm 3 ; 39.1 ± 10.3 vs 33.5 ± 9.4 cm 3 ; P  = .0001); total IPSS was higher in CAD and CAE patients compared with that of the control subjects ( P  = .0001). Postmictional residual urine volume was higher in CAE and CAD patients compared with that of the control subjects ( P  = .002). Conclusion We showed that patients with CAE have higher prostate volume, IPSS, and postmictional residual urine volume compared with those of controls with normal coronary angiograms. This study proposes that BPE, LUTS, and CAE maybe different disorders to a common vascular pathology and endothelial dysfunction. This study showed that BPE and LUTS were frequently seen in CAE at least as much as in CAD. Therefore, LUTS and BPE should be kept in mind for CAE patients in follow-ups.