ESTUDO DE EQUIVALÊNCIA FARMACÊUTICA ENTRE COMPRIMIDOS DE FUROSEMIDA SIMILARES E GENÉRICOS

Furosemide is a medicine widely used in hypertensive therapy, congestive heart failure, oedema of cardiac, renal and hepatic origin. Because it is a loop diuretic, due to its role in the thick segment of the Henle loop, it is considered very potent for these diseases. Pharmaceutical equivalence aims to promote comparative quality tests between the reference drug and the drug to be tested. Test and reference medicinal products must present the same concentrations, pharmaceutical forms, physical and physicochemical characteristics. In this study, the drug furosemide 40 mg was used, where two generic brands were tested (G1 and G2), and two similar ones (S1 and S2) comparing them with the reference (R). Regarding weight variation, friability, disintegration, hardness, dissolution, dosing and the total number of mesophilic microorganisms, it can be said that the drugs are pharmaceutical equivalents.