DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

Symen Ligthart,Carola Marzi,Stella Aslibekyan,Michael M. Mendelson,Karen N. Conneely,Toshiko Tanaka,Elena Colicino,Lindsay L. Waite,Roby Joehanes,Weihua Guan,Jennifer A. Brody,Cathy E. Elks,Riccardo E. Marioni,Min A. Jhun,Golareh Agha,Jan Bressler,Cavin K. Ward-Caviness,Brian H. Chen,Tianxiao Huan,Kelly M. Bakulski,Elias Salfati,Giovanni Fiorito,Simone Wahl,Katharina Schramm,Jin Sha,Dena Hernandez,Allan C. Just,Jennifer A. Smith,Nona Sotoodehnia,Luke C. Pilling,James S. Pankow,P.S. Tsao,Chunyu Liu,Wei Zhao,Simonetta Guarrera,Vasiliki Michopoulos,Alicia K. Smith,Marjolein J. Peters,David Melzer,Pantel Vokonas,Myriam Fornage,Holger Prokisch,Joshua C. Bis,Audrey Y. Chu,Christian Herder,Harald Grallert,Chen Yao,Sonia Shah,Allan F. McRae,Honghuang Lin,Steve Horvath,Daniele Daniele Fallin,Albert Hofman,Nicholas J. Wareham,Kerri L. Wiggins,Andrew P. Feinberg,John M. Starr,Peter M. Visscher,Joanne M. Murabito,Sharon L.R. Kardia,Devin Absher,Elisabeth B. Binder,Andrew Singleton,Stefania Bandinelli,Annette Peters,Melanie Waldenberger,Giuseppe Matullo,Joel Schwartz,Ellen W. Demerath,André G. Uitterlinden,Joyce B. J. van Meurs,Oscar H. Franco,Yii-Der Ida Chen,Daniel Levy,Stephen T. Turner,Ian J. Deary,Kerry J. Ressler,Josée Dupuis,Luigi Ferrucci,Ken K. Ong,Themistocles L. Assimes,Eric Boerwinkle,Wolfgang Koenig,Donna K. Arnett,Andrea Baccarelli,Emelia J. Benjamin,Abbas Dehghan

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

2016

Symen Ligthart
Carola Marzi
Stella Aslibekyan
Michael M. Mendelson
Karen N. Conneely
Toshiko Tanaka
Elena Colicino
Lindsay L. Waite
Roby Joehanes
Weihua Guan
Jennifer A. Brody
Cathy E. Elks
Riccardo E. Marioni
Min A. Jhun
Golareh Agha
Jan Bressler
Cavin K. Ward-Caviness
Brian H. Chen
Tianxiao Huan
Kelly M. Bakulski
Elias Salfati
Giovanni Fiorito
Simone Wahl
Katharina Schramm
Jin Sha
Dena Hernandez
Allan C. Just
Jennifer A. Smith
Nona Sotoodehnia
Luke C. Pilling
James S. Pankow
P.S. Tsao
Chunyu Liu
Wei Zhao
Simonetta Guarrera
Vasiliki Michopoulos
Alicia K. Smith
Marjolein J. Peters
David Melzer
Pantel Vokonas
Myriam Fornage
Holger Prokisch
Joshua C. Bis
Audrey Y. Chu
Christian Herder
Harald Grallert
Chen Yao
Sonia Shah
Allan F. McRae
Honghuang Lin
Steve Horvath
Daniele Daniele Fallin
Albert Hofman
Nicholas J. Wareham
Kerri L. Wiggins
Andrew P. Feinberg
John M. Starr
Peter M. Visscher
Joanne M. Murabito
Sharon L.R. Kardia
Devin Absher
Elisabeth B. Binder
Andrew Singleton
Stefania Bandinelli
Annette Peters
Melanie Waldenberger
Giuseppe Matullo
Joel Schwartz
Ellen W. Demerath
André G. Uitterlinden
Joyce B. J. van Meurs
Oscar H. Franco
Yii-Der Ida Chen
Daniel Levy
Stephen T. Turner
Ian J. Deary
Kerry J. Ressler
Josée Dupuis
Luigi Ferrucci
Ken K. Ong
Themistocles L. Assimes
Eric Boerwinkle
Wolfgang Koenig
Donna K. Arnett
Andrea Baccarelli
Emelia J. Benjamin
Abbas Dehghan

Background Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation.

Keywords:

Genetics
Inflammation
Human genetics
Subclinical infection
C-reactive protein
DNA methylation
Bioinformatics
Immune system
Biology
Pathogenesis
Genome-wide association study

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