The mouse 5-HT2B receptor: possible involvement in trophic functions of serotonin.

The novel serotonin receptor 5-HT 2B shows the highest homology to the 5-HT 2 family of receptors. The pharmacological profile of membranes from 5-HT 2B cDNA stably transfected LMTK- cell line, corresponds to a new 5-HT 2 -like receptor named 5-HT 2B , although some difference exists between the mouse and rat pharmacology. A similar pharmacological profile is detected on the immortalized teratocarcinoma-derived cell line 1C11 upon 2 days of serotoninergic differenciation by cAMP. In both cell lines, the analysis 125 I-DOI binding reveals the presence of a single class of sites, the affinity of which is one order of magnitude lower than the one reported for the 5-HT 2A receptor