AB1103 NEUROLOGICAL IMPAIRMENT DURING SARCOIDOSIS

Background Objectives To describe neurological impairment characteristics in sarcoidosis. Methods This was a descriptive and retrospective study including 65 patients with sarcoidosis, followed in the departments of internal medicine and neurology at the Military Hospital of Tunis over a period of 20 years from 1997 to 2017. Results A total of 65 patient files have been selected, of which 38 have neurological involvement. Thirty-eight patients met the inclusion criteria for Neurosarcoidosis. According to Zajicek’s criteria, the diagnosis of neurosarcoidosis was certain in 2 cases, probable in 18 cases and possible in 18 cases. Neurological disorders were symptomatic in 58.5% of the studied population. Neurological signs were inaugural in 9 patients (14% of cases). A central neurological involvement was demonstrated in 33 patients (86.8%), the peripheral nervous system was affected in 5 patients (13.1%), and cranial nerve involvement was found in 10 patients (26.3%).%). Ten patients have had both central and peripheral impairement. Neurological involvement was significantly associated with cardiac, renal extra-thoracic, ophthalmologic, articular and cutaneous involvement (p Genotyping of the conversion enzyme and HLA typing did not show any particular pattern of neurosarcoidosis in comparison with patients without neurological signs. Conclusion Neurological impairement was frequently observed in our series. It was also significantly associated with multivisceral involvement without particular genetic pattern. Disclosure of Interests None declared