One of sodium cefuroxime new industrial crystallization method and formulation

The present invention discloses a novel technique for industrial crystallization of sodium cefuroxime, by way of supercritical fluid extraction and crystallization techniques conventional in combination to achieve recrystallization of sodium cefuroxime. Throughout the crystallization system, at a specific temperature and pressure conditions, under the action of the supercritical fluid, solvent extraction cell, crystallization pond complete extraction, adsorption, crystallization and drying process, achieve a weight of cefuroxime sodium crystallization. High separation efficiency of the present method, less impurities, greatly improving the quality of the product formulation.