The First One-Pot Synthesis of L-7-Iodotryptophan (IIIe) from 7-Iodoindole and Serine, and an Improved Synthesis of Other L-7-Halotryptophans.

Duncan R. M. Smith,Tom Willemse,Danai S. Gkotsi,Wim Schepens,Bert U. W. Maes,Steven Ballet,Rebecca J. M. Goss

The First One-Pot Synthesis of L-7-Iodotryptophan (IIIe) from 7-Iodoindole and Serine, and an Improved Synthesis of Other L-7-Halotryptophans.

2014

Duncan R. M. Smith
Tom Willemse
Danai S. Gkotsi
Wim Schepens
Bert U. W. Maes
Steven Ballet
Rebecca J. M. Goss

A bacterial cell lysate containing tryptophan synthase is developed to enable a scalable one-pot biotransformation of indoles to the corresponding tryptophans with serine as coupling partner.

Keywords:

Bacterial cell structure
Stereochemistry
Tryptophan synthase
Lysis
Biotransformation
Serine
One-pot synthesis
Chemistry
Organic chemistry

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