Clearance of the intracellular high level of the Tau protein directed by an artificial synthetic hydrolase
2014
Promoting clearance of intracellular excessive tau is a potential therapeutic strategy for treating Alzheimer's disease. In this work, we designed and synthesized a cyclen-hybrid artificial ‘hydrolase’ I1-Cu(II) to cleave tau in vitro. Furthermore, a cell-permeable ‘hydrolase’ I2-Cu(II), derived from I1-Cu(II), was also synthesized to cleave intracellular tau proteins.
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