Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese (II) superoxide dismutase mimic complex

A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe was studied in a cellular model of oxidative stress. Its speciation was questioned using Re and Mn X-fluorescence. Its distribution were compared to its unconjugated analogue. Interestingly, their similar activities mirror their similar concentrations in mitochondria.