Synthesis method of Sertaconazole nitrate

The invention discloses a synthesis method of Sertaconazole nitrate. The method comprises steps as follows: DMF (dimethylformamide), imidazole and caustic soda flakes are added to a reaction container, evenly mixed, slowly heated to the temperature of 110-115 DEG C, kept at the temperature for 1 h and then cooled to the temperature of 50-55 DEG C; a DMF solution of 2-chloro-1-(2,4'-dichlorophenyl)-ethyl alcohol is dropwise added, the temperature is controlled to range from 50 DEG C to 55 DEG C and kept for 1 h after addition, the mixture is heated to the temperature of 110-115 DEG C and kept at the temperature for 4 h, caustic soda flakes are added, a DMF solution of 2-chloro-3-chloromethyl thiophene is dropwise added, the temperature is controlled to range from 50 DEG C to 55 DEG C and kept for 1 h, the mixture is heated to the temperature of 110-115 DEG C for a reaction for 3 h in the temperature range, water is added, and the mixture is cooled to the room temperature; nitric acid is added for acidification, centrifugal filtration is performed, and a crude Sertaconazole nitrate product is obtained through centrifugal filtration; the crude product is dried and recrystallized with methylbenzene, and a dry product is obtained. According to the method, used equipment is simple, steps are simplified, the production cost is low, and the method is suitable for industrial production.