Down-regulated NOD2 by immunosuppressants in peripheral blood cells in patients with SLE reduces the muramyl dipeptide-induced IL-10 production.

Shui-Lian Yu,Chun Kwok Wong,Purple T. Y. Wong,Da-Peng Chen,Cheuk-Chun Szeto,Edmund K. Li,Lai-Shan Tam

Down-regulated NOD2 by immunosuppressants in peripheral blood cells in patients with SLE reduces the muramyl dipeptide-induced IL-10 production.

2011

Shui-Lian Yu
Chun Kwok Wong
Purple T. Y. Wong
Da-Peng Chen
Cheuk-Chun Szeto
Edmund K. Li
Lai-Shan Tam

Background Pattern recognition receptors (PRRs) such as Toll-like receptors are aberrantly expressed of peripheral blood mononuclear cells (PBMCs) in systemic lupus erythematosus (SLE) patients, for playing immunopathological roles.

Keywords:

Dendritic cell
Toll-like receptor
Immune system
Muramyl dipeptide
Plasmacytoid dendritic cell
NOD2
Lupus erythematosus
Immunology
Peripheral blood mononuclear cell
Biology
Receptor
Downregulation and upregulation
Interleukin 10
Pattern recognition receptor

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