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Total and Free Plasma Concentrations of Progesterone, Cortisol and Oestradiol-I7ß during Pregnancy, Parturition and Early Lactation in Sows
1984
The total (bound plus free) concentrations of progesterone, 20a-free fractions of progesterone, oestradiol-17{3 and cortisol were measured in the same samples by a rate dialysis method. Up to day 110 of gestation, the amounts of free hormone in plasma did not fluctuate independently of their total concentrations. During farrowing, the total and free concentrations of progesterone and cortisol varied independently of each other, whereas total and free oestradiol-17{3 declined simultaneously. The initiation of parturition was associated with a decrease in circulating total progesterone, and was accentuated by a decrease in the free fraction (Pfree concentration was only 20% of its day 1 pre-partum value. Total and free cortisol concentrations rose rapidly during labour so that at 12-18 h after birth of the first piglet 30% of that cortisol in maternal plasma was free hormone.
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