幽门螺杆菌感染胃癌组织MMP-2和MMP-9表达及其对胃癌侵袭转移能力的影响

AIM: To detect the expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in gastric tissues with H pylon infection, and to analyze the effect of H pylon infection on the invasion and metastasis of gastric cancer. METHODS: A total of 42 cases of gastric cancer specimens were included in this study. H pylon infection was determined by improved Giemsa method and the expression of MMP-2 and MMP-9 were detected by immunohistochemistry. Fisher's exact was used to analyze the correlation between H pylon infection and the clinical pathological features of gastric cancer. RESULTS: H pylon infection was confirmed in 26 of 42 cases, and it was correlated with the staging and lymph node metastasis, but not with the sex, age of patients and histological types. H pylon infection was also significantly correlated with the expression of MMP-9 and MMP-2 (x^2=7.77, P＜0.01; x^2=P＜0.01). CONCLUSION: H pylon infection may promote the invasion and metastasis of gastric cancer by increasing the expression of MMP-2 and MMP-9.