Effect of middle mass molecules from blood sera of patients with burns on the process of lipid peroxidation

: Effects of "middle mass molecules", isolated from blood sera of patients with acute burn toxemia, on ascorbate-, NADPH-dependent and spontaneous lipid peroxidation were studied in homogenates of mice brain and liver tissues. The "middle mass molecules" inhibited distinctly the lipid peroxidation, the rate of which correlated with concentration of the "middle mass molecules" in the medium. Inhibition of lipid peroxidation appears to be one of factors responsible for neuro- and psychotropic effects characteristic for these molecules.