Divergent synthesis of (6S,1′S,2′R)-hydroxypestalotin via tandem conjugate addition–lactonization sequence

Abstract The stereoselective synthesis of (6 S ,1′ S ,2′ R )-hydroxypestalotin from trans -hex-2-en-1-ol utilizing asymmetric dihydroxylation and Luche’s reduction and tandem conjugative addition–lactonization as the key steps is reported.