Reduction of migrainous headaches during the use of acenocoumarol

Disappearance of migraine during the use of warfarin and of phenprocoumon has been described in sporadic case reports. Treatment with heparin has also been associated with a reduction of migranous headaches. Recently, the Netherlands Pharmacovigilance Foundation LAREB received a case report concerning the diminution of migrainous headaches associated with the use of the vitamin K antagonist, acenocoumarol.