I25 Testing for cytoplasmic abnormalities: Mitochondrial haplogroup and aneuploidy – any correlation?

the main indication, followed by hematological malignancies. As a result of those IVF cycles, 89 healthy and HLA matched babies were born. aHSCT have been performed for 44 children so far, where transplantation has been successful in 40 children whose post-transplantational clinical conditions demonstrated hematopoietic and immunological reconstitution. Unfortunately, in 4 cases with beta-thalassemia, graft failure occurred after aHSCT. The follow up of families and siblings born after preimplantation HLA typing is crucially important for the demonstration of the feasibility and the success of this technique. The results of this large patient set, which is from one center demonstrates that preimplantation HLA typing is a reliable technique which provides a realistic option for the couples in the treatment of an affected child in need of HSCT when no HLA matched donor is available.