Anti-inflammatory analgesia mutual prodrug of non-steroidal antiinflammatory drug and preparation method thereof

Non-steroidal anti-inflammatory analgesic mutual prodrug, wherein: the mutual prodrug via an ester bond connecting the two drug molecules having a non-steroidal anti-inflammatory analgesic or antipyretic analgesic effect; having the structure through formula: (1) wherein: R1 is a substituted alkyl or aryl group. Compared with the prior prodrugs nonsteroidal anti-inflammatory drug, the mutual prodrugs of the present invention is significant pharmacodynamic activity, high safety, and the human body in vivo metabolites clear process.