Topical formulations antivirals for prevention of transmission of HSV-2

antiviral compound (R) - (1- (6-amino-9 H -purin-9-yl) propan-2-yloxy) methyl phosphonic acid (tenofovir) for use in reducing or preventing the transmission of HSV-2 a mammal wherein tenofovir vaginally applied to a human female as a gel formulation comprising ** ** Table