Electronic microarray for DNA analysis Review Article

Summary Nanogen has developed a microelectronic technology that allows fast and accurate transport and hybridization of DNA on a semiconductor microchip. Based on this technology, we have developed electronic assays for genetic analysis of single nucleotide polymorphisms in several different applications. We have also developed electronic hybridization based short tandem repeats analysis for genetic identification and forensics. Our data show that these assays work in multiple formats under different electronic conditions. A beta instrument is capable of performing these tests on 100-site arrays in a semi-automated fashion. We are also working towards developing an integrated system, which could potentially become a portable device.