Highly enantioselective oxidative tandem cyclization reaction: a chiral ligand and an anion cooperatively control stereoselectivity
2014
The unprecedented combination of a palladium(II) complex with a chiral Bu-QUOX ligand and a chiral phosphoric acid enables the highly efficient asymmetric oxidative tandem cyclization of N-(2,2-disubstituted hex-5-en-1-yl)acrylamides, providing a straightforward method to access chiral 6,5-bicyclic aza-heterocycles in moderate to good yields and with excellent enantioselectivities.
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