expression in cervical intraepithelial neoplasia specimens, including women with HIV-1

is a cyclin-dependent kinase inhibitor that regulates the transition from the G1 to S phase and nega-tively influences cell proliferation in conjunction with other tumour suppressor proteins, such as the retino-blastoma gene (pRb) (Tringler et al. 2004). As pRb is functionally inactivated by the high-risk human papillo-human papillo-ma virus (HPV) oncoprotein E7, there is a concomitant overexpression of p16