Application of system for detecting expression quantity of eight miRNAs in preparation of product for diagnosing or assisting in diagnosing hepatocellular carcinoma
2016
The invention discloses application of a system for detecting the expression quantity of eight miRNAs in preparation of a product for diagnosing or assisting in diagnosing hepatocellular carcinoma. The hepatocellular carcinoma can be well diagnosed with a model built by the content of the eight RNAs including has-miR-20a, hsa-miR-21, hsa-miR-26a, hsa-miR-122, hsa-miR-192, hsa-miR-146a, hsa-miR-223 and hsa-miR-483-5 in blood plasma, the sensitivity can reach 69.6%, the specificity can reach 92.8%, the accuracy rate can reach 83.3%, and the sensitivity obtained when the eight miRNAs and AFP are utilized to perform joint diagnosis on the hepatocellular carcinoma can reach 85.7%. Therefore, the miRNAs in the blood plasma can diagnose the hepatocellular carcinoma by serving as a tumor diagnosis marker and also can diagnose the hepatocellular carcinoma together with the AFP.
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