Expression of Ezrin and inducible nitric oxide synthase and their correlation in colonic adenoma

Objective To investigate the expression of Ezrin and inducible nitric oxide synthase (iNOS) and their correlation to malignant proliferation of colonic adenoma. Method Expressions of Ezrin,iNOS and nuclear Ki-67 antigen were detected by immunohistochemistry in tubular adenoma (60 cases),villous adenoma (40 cases) and malignant (30 cases ) pleomorphic adenoma. Results Expressions of Ezrin,iNOS in tubular adenoma [58.3％ (35/60), 50.0％ (30/60)], villous adenoma [72.5％ (29/40), 70.00(28/40)]and malignant pleomorphic adenoma [96.7％(29/30),93.3％(28/30)]were gradually increased ( X2 = 11.600,P = 0.005; X2 = 8.451, P = 0.015 ). There was a significant positive correlation between the expression of Ezrin and iNOS (r = 0.765, P ＜ 0.01 ). Nuclear Ki-67 antigen proliferation index was increased with the increasing of Ezrin and iNOS expressions. Conclusion Overexpression of Ezrin and iNOS may promote proliferation and malignant transformation of colonic adenoma. Key words: Adenomatous polyposis coli;  Nitric oxide synthase;  Ezrin;  Ki-67 nuclear antigen