Correlation between endoscopic and histological validated scoring indices in Crohn’s disease

Abstract Background It is of crucial importance to evaluate disease activity by means of endoscopy and histopathology in Crohn’s disease (CD). Nonetheless, correlation between endoscopic and histological validated indices has not been verified. Aims We aim to correlate the Simple Endoscopic Score for Crohns disease (SES-CD) with two validated widely used histological indices in patients with established CD. Methods The SES-CD at the worst affected area was scored and histological disease activity using Global Histologic Disease Activity Score (GHAS or D’Haens score) and the Naini and Cortina Score (NCS) was scored independently by two pathologists blinded to the clinical information and endoscopic results. Spearman correlation between the SES-CD, GHAS and NCS were performed. Results 143 patients, 32 with SES-CD scores 0–2, 57 with 3–6, 37 with 7–15, and 17 with ≥16. Correlation coefficients between SES-CD and GHAS were r = 0.86 (95% CI 0.80–0.91, p  Conclusions The SES-CD strongly correlates with both GHAS and NCS. The SES-CD of 0 to 1 best represents histological remission that correlates with quiescent disease activity.