Abstract 20776: Glomerular Hyperfiltration and Microalbuminuria as Predictors of Cardiovascular Events in the Abp-International Study

Objective: The association between glomerular hyperfiltration (GHF), microalbuminuria and cardiovascular events (CVE) is poorly known. Hypothesis: We tested the hypothesis that GHF is associated with risk of adverse cardiovascular outcome independently of microalbuminuria in a multiethnic population. Methods: The analysis was performed in 8794 participants aged 52±16 years (55.0% men) enrolled in 8 prospective studies in Australia, Italy, Japan, and U.S.A.. Hypertension was present in 88.7% of the participants. All were untreated at baseline assessment. Using the 5th and 95th percentiles of the age and sex specific quintiles of CKD-EPI-calculated estimated glomerular filtration rate (eGFR), we identified 3 groups: low (LF), high (GHF) and normal (NF) eGFR. Urinary albumin data were obtained in 6401 participants. The independent prognostic role of eGFR categories and microalbuminuria was tested using study-stratified multivariable Cox models. Results: The median (IQR) eGFR were: 48.2 (38.1, 58.7), 81.4 (69...