The Effect of Non-Activated Prothrombin Complex Concentrate (Proplex ® ST) on Intraperitoneal Hematoma in a Hemophilia A Patient with a Factor VIII Inhibitor

A 28-year-old severe hemophiliac with a factor VIII inhibitor was admitted to our hospital with a massive and serious intraperitoneal hematoma. He was a high-responder patient showing maximal serum inhibitor levels as high as 255 Bethesda Units/ml (BU/ml). He was successfully treated with "bypass therapy" using a prothrombin complex concentrate (PCC). (Internal Medicine 35: 319-322, 1996)