Febuxostat dispersing tablet preparation and preparation method thereof

2009 
The invention relates to a febuxostat dispersing tablet preparation and a preparation method thereof. The febuxostat dispersing tablet preparation is especially suitable for patients having poor adaptability or difficulties in taking common solid preparations, such as tablets and capsules and is prepared from the following materials in parts by weight: 40-150 parts of febuxostat, 50-200 parts of microcrystalline cellulose, 5-20 parts of croscarmellose sodium, 10-30 parts of polyvinylpolypyrrolidone, 50-200 parts of lactose, 1-10 parts of aspartame, 0.5-5 parts of magnesium stearate and 0.5-5 parts of hydroxypropyl methylcellulose. The preparation method of the febuxostat dispersing tablet preparation ahs the steps of: sieving the raw materials by a 100-mesh sieve, weighting the raw materials in proportion and and uniformly mixing, tabletting, crushing, sizing by 24 meshes, adding magnesium stearate in proportion, mixing and tabletting. The invention can be rapidly disintegrated and dispersed in water into an even suspended solution and have the advantages of good taste, stable quality, high bioavailability, convenient taking, and the like.
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