Ameliorating Effect of Piperine on NO-cGMP Pathway in Stress Induced Depression

Depression has become a common illness among individuals of every age group. Among numerous factors held responsible for depression stress is most vital. Behind the specified disorder various hypothesis has been laid out where Nitric Oxide is emerging target to treat stress induced depression. Antidepressant potential of piperine in stressed and unstressed condition was evaluated using tail suspension test and forced swim test whereas locomotor activity was evaluated by actophotometer. Results of the present study indicate the potential of antidepressant effect of piperine in stress. Methylene blue potentiated the effect of sub- effective dose of PP and SB-203580 enhanced effect of Piperine in stressed mice with no array on locomotor activity with direct influence on Nitric oxide. Piperine produced significant changes in Nitric oxide level which is pathophysiologic mediator(s) of depression, which validate the action of piperine on depression symptoms.