Clinical and histopathological analysis of ocular lymphocytic inflammatory pseudotumors

: 44 cases (56 eyes of 29 males and 15 females) of lymphocytic inflammatory pseudotumor were analysed. The average age of onset was 40.6 years. The chief manifestations consisted of orbital mass, proptosis, edema of the eyelids and bulbar conjunctiva, and limited eyeball motility. ESR was accelerated in 11 of 13 patients tested. Seral antibody of EB virus was positive in 2 of 3 patients examined. Immunohistochemically, all 3 patients examined showed polyclonality. A diffuse lymphocytic infiltration with other inflammatory cells and fibrovascular proliferation was the basic pathological picture. Histopathologically, the disease was classified into the diffuse infiltrative, fibrotic, and mixed types. The pathogenesis, the significance of immunohistochemical examinations, and treatment were discussed.