Identification of Chemical Compounds That Inhibit the Function of Histidyl-tRNA Synthetase from Pseudomonas aeruginosa:

Yanmei Hu,Stephanie O. Palmer,Sara T. Robles,Tahyra Resto,Frank B. Dean,James M. Bullard

Identification of Chemical Compounds That Inhibit the Function of Histidyl-tRNA Synthetase from Pseudomonas aeruginosa:

2018

Yanmei Hu
Stephanie O. Palmer
Sara T. Robles
Tahyra Resto
Frank B. Dean
James M. Bullard

Pseudomonas aeruginosa histidyl-tRNA synthetase (HisRS) was selected as a target for antibiotic drug development. The HisRS protein was overexpressed in Escherichia coli and kinetically evaluated. ...

Keywords:

Histidyl-tRNA synthetase
Antibiotics
antibiotic drug
Protein biosynthesis
TRNA aminoacylation
Chemistry
Drug discovery
Escherichia coli
Pseudomonas aeruginosa
Biochemistry

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