Phytochemical and biological investigation of the red sea marine sponge Hyrtios sp

Three compounds including indole-3- carbaldehyde (1) 5, 6-dibromoindole- 3-carboxaldehyde (2) and Ergosterol (3) were isolated from Red Sea sponge Hyrtios sp. The structures of compounds 1-3 were determined by spectroscopic analyses including 1D and 2D NMR, and HR-ESI-MS experiments as well as comparison to literature. These results demonstrate that sponges are rich sources for natural products with new pharmacological activities and relevance to drug discovery, some biological investigations were carried out to the total extract and some fractions of Hyrtios sp as anti-inflammatory, anti-pyretic, analgesic activities and showed that the sponge Hyrtios has significant biological activities.