Inhibition of Plasmodium berghei sporozoite invasion of cultured hepatoma cells

Abstract Monoclonal antibody to a Plasmodium berghei surface antigen blocked sporozoite invasion of cultured human hepatoma cells. Such antibodies were of IgG 1 class. Two monoclonals of the IgM class, probably reactive with the same antigen, did not neutralize invasion. It appears that the sporozoite surface antigen mediates invasion of hepatoma cells.