Protective effect of arctigenin against MPP+ and MPTP-induced neurotoxicity.
2014
The potential protective effects of arctigenin on 1-methyl-4-phenylpyridinium
ion and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyride-induced neurotoxicity
were examined, and the results indicated that arctigenin could improve the
movement behaviors and upregulate dopamine and γ -aminobutyric acid
levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyride-induced neurotoxicity
mouse model. A further in vitro experiment showed that the
pretreatment with arctigenin on cultured human neuroblastoma SH-SY5Y cells
could obviously attenuate the decrease of cell survival rates caused by
treatment with 1-methyl-4-phenylpyridinium ion by way of acting against cell
apoptosis through the decrease of Bax/Bcl-2 and caspase-3, and by
antioxidative action through reduction of the surplus reactive oxygen
species production and downregulation of mitochondrial membrane potential.
It is for the first time that a neuroprotective activity of arctigenin in
both in vitro and in vivo experiments was reported,
enlightening that arctigenin could be useful as a potential therapeutic
agent for Parkinsonʼs disease.
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