The Management of Duodenal Ulcer Relapse

Duodenal ulcers are characterized by remissions and relapses. Various recommendations have been made to render the patient symptom-free; these include the use of diet; intermittent, continuous, and on-demand treatment with H2 antagonists; surgery; and mucosal protective agents. Campylobacter pylori has been associated with duodenal ulcer relapse. Eradication of the organism may prevent relapse. Treatment with colloidal bismuth subcitrate, which has antibacterial activity, results in lower relapse rates. More effective eradication of C. pylori may alter the natural history of peptic ulcer.