TPBG antibody, and preparation method, conjugate and application thereof

The invention discloses a TPBG antibody, and a preparation method, a conjugate and an application thereof. The TPBG antibody comprises one or more of a heavy chain CDR1, a heavy chain CDR2 and a heavy chain CDR3 in the heavy chain variable region of the TPBG antibody, and/or one or more of a light chain CDR1, a light chain CDR2 and a light chain CDR3 of the light chain variable region of the TPBG antibody, and the amino acid sequences of all above heavy chains and light chains are respectively shown in the description. The TPBG antibody is a humanized antibody and has high affinity, and the conjugate prepared by coupling the TPBG antibody with a micro-molecular drug toxin MMAF has a cytotoxin killing effect on TPBG positive cells, so the conjugate can be used in the preparation of tumor treatment drugs.