Erythema multiforme associated with Mycoplasma pneumoniae

A 21-year-old-woman with no relevant medical history presented with a 1-week history of sore throat, fever and itchy rash. The examination revealed erythema in the oropharynx and vesiculopustular exudative lesions 2–3 cm in diameter over the face and erythematous vesicular ‘‘target’’ lesions in the trunk, upper limbs and the back of both hands (Fig. 1a–c). Laboratory tests, with the exception of the C-reactive protein level (4 mg/dL), were all normal. Blood cultures and cultures from skin lesions (for both virus and bacteria) were negative. However, the serological test for Mycoplasma pneumoniae (IgM; microparticle agglutination assay) was positive. Treatment with intravenous levofloxacin and topical mupirocin was initiated and the skin lesions gradually improved and the fever disappeared. A biopsy of the lesions was not performed given the improvement of the patient with the Fig. 1 Vesiculopustular exudative lesions over the face and vesicular ‘‘target’’ lesions in the neck and the hands highly suggestive of erythema multiforme