Taxdol self-assembled precursor liposome and its preparation method

Liposome precursors and their preparation of the present invention discloses a method for self-assembly of paclitaxel. The self-assembly precursor material liposome formulation containing the following percentages by weight: 0.1 to 5% paclitaxel, 1 to 40% of phospholipids, 5 to 25% polyethylene glycol modifier, a dispersion medium, 40 to 70%; Preparation method take each raw material formulated into a container and allowed mixed and dispersed to give a clear liquid, the porous membrane filter press is sealed in the container can be nitrogen. After the precursor liposomes immediately before use by diluting the appropriate clinical dose fast hydration medium may self-assemble into a uniform particle size, high encapsulation efficiency of the drug-containing liposomal formulation, can be used for intravenous administration. The present invention using conventional process equipment, high production efficiency, product quality and stability, good through the needle, the effective storage period of more than 2 years; stabilized liposomes formed after hydration quality to meet the needs of clinical administration, which process is simple, low cost and easy industrial production.