First live birth after ovarian stimulation using a chimeric long-acting human recombinant follicle-stimulating hormone (FSH) agonist (recFSH-CTP) for in vitro fertilization ☆

Objective: To report the first pregnancy and live birth after ovarian stimulation using a chimeric long-acting human recombinant FSH agonist (recFSH-CTP) for IVF. Design: Case report. Setting: Tertiary fertility center. Patient(s): A 32-year-old woman with a 7-year history of primary infertility. Intervention(s): Ovarian stimulation with a single SC injection of 180 μg recFSH-CTP on cycle day 3, followed by daily injections of 150 IU recFSH from cycle day 10 onward, combined with daily GnRH antagonist 0.25 mg SC to prevent a premature LH rise. Final oocyte maturation was induced by 10,000 IU hCG. Main Outcome Measure(s): First ongoing pregnancy obtained with recFSH-CTP. Result(s): Twelve oocytes were retrieved. Ten oocytes were fertilized in vitro by intracytoplasmic sperm injection, and from these 10 oocytes, two embryos were subsequently transferred after 3 days of culture. A pregnancy test 2 weeks after ET was positive, and ultrasound investigation revealed an intact, intrauterine, singleton pregnancy after 12 weeks. Conclusion(s): The first pregnancy and live birth was achieved after ovarian stimulation using recFSH-CTP for IVF.