Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise

Abstract Background The aim of our study was to evaluate the effect of programmed physical activity and a single exercise test on the number of CD309 + circulating endothelial progenitor cell (EPC) and their relation to the variation in plasma levels of VEGF in chronic coronary patients. Methods 21 patients Results VEGF values decreased significantly after exercise SPECT test. After one month, there was a significant increase in VEGF levels compared to those measured immediately after exercise. All patients showed a decrease in the values of EPC at 1 and 3-month follow-up. There was an inverse and statistically significant relation between change of EPC and VEGF between the baseline and 1 month. Conclusions The increase of VEGF at 1-month, with respect to baseline values correlated with decreased levels of EPC. This association was independent of the onset of ischemia in the perfusion study.