Rolul antioxidanţilor neenzimatici în diminuarea stresului oxidativ asociat creşterii şi dezvoltării tumorilor maligne

The active species of oxygen are produced as a result of normal aerobic metabolism. Of these, free radicals are usually remetabolized or inactivated in vivo by whole team of antioxidants. Individual team members of the antioxidant fight are specialized to prevent ROS generation by destroying the oxidative potential or capture them. In physiological conditions, tissue attack induced by the oxidative stress is minimal. A relative deficiency or absolute in antioxidant defenses can cause increased oxidative stress, and this event is associated with both causes and consequences of some diseases, including cancer. The purpose of this paper is to identify the role of antioxidant defense systems and diminishing oxidative stress in the dynamic growth and development of malignancies. Our study in vivo was held on Wistar rats bearing Walker 256 carcinoma, receiving non-enzymatic antioxidants vitamin C, vitamin A, Zn and arginine in various combinations. Treatment was initiated three weeks before tumor induction.