Association of uric acid and C-reactive protein with severity of preeclampsia in Iranian women

This study was planned to determine the levels of uric acid (UA) and CRP at preeclampsia and their association with the severity of the disease. In a cross-sectional, case-control study we measured UA and CRP levels in blood samples from 46 women with preeclampsia, 23 normal pregnant women and 23 non pregnant women matched for age, BMI, parity and gestational age were measured. Twenty three patients had developed severe and 23 mild preeclampsia. UA and CRP were measured by enzymatic method and enzyme-linked immunosorbent assay, respectively. Roc curve was used to determine the optimal cutoff value. Results showed CRP and UA concentrations were higher in Preeclamptic group (33.77±25.97, 5.93±0.75) compared with normal pregnant group (17.31±19.54, 5.47±0.41). CRP levels were also significantly elevated in women with severe preeclampsia compared to those mild preeclampsia (42.26±24.04, 16.81±22.03). Determination of serum CRP levels may be used as marker for the severity of preeclampsia. We also suggest that serum UA level of 5.5 mg dL -1 is best cutoff point for the diagnosis of preeclampsia.