Возможности применения аторвастатина у больных ревматоидным артритом с гиперхолестеринемией

Background. In rheumatoid arthritis, progression of atherosclerosis caused not only by hypercholesterolemia, and also by immunological mechanisms underlying the pathogenesis of this disease. Methods. The clinical and laboratory parameters were examined, including the levels of DAS28, cytokines and metalloproteinases in 42 rheumatoid arthritis patients with hypercholesterolemia before and after 6 weeks of treatment with atorvastatin (20 mg/day). Results. The use of atorvastatin in addition to basic therapy resulted a reduction in the activity of rheumatoid arthritis and levels of clinical and laboratory markers. Conclusions. The given results determine the prospects for the use of statins for the prevention of hypercholesterolemia, cardiovascular complications and early mortality in patients with rheumatoid arthritis.