Multiparameter Analysis of EEG in Old Wistar Rats after Bilateral Carotid Artery Ligation

We showed that 302 of 840 EEG parameters in old Wistar rats significantly change 3 h after bilateral carotid artery ligation. All animals (n=7) died 250±47 min after ligation. EEG power spectra had signs of suppression (increased δ-activity, decreased τ-activity, and increased low-frequency α-activity) or activation of CNS (decreased high-frequency α-activity and paroxysmal increase in β-activity). The coherence, synchrony, and entropy of potentials were reduced in the majority of brain regions. This method and scheme of experiments are suitable for the search and study of anti-stroke drugs.